Fan, Sheng-Bin;
Huang, Hung-Ling;
Tu, Hung-Pin;
Sobkowiak, Benjamin;
Cheng, Meng-Hsuan;
Huang, Wei-Chang;
Huang, Yi-Wen;
... Lu, Po-Liang; + view all
(2025)
The Resistance Trends in Mycobacterium kansasii Pulmonary Isolates and identification of risk factors for drug resistance in Taiwan.
Journal of Global Antimicrobial Resistance
10.1016/j.jgar.2025.11.001.
(In press).
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Abstract
Objectives: Mycobacterium kansasii (M. kansasii) pulmonary disease is an emerging global health concern, and the pathogen's resistance to antimicrobial agents is challenging. Understanding the epidemiology of drug resistance rates and the associated risk factors is useful for guiding antimicrobial agent selection for M. kansasii treatment. Methods: This retrospective cohort study analysed 361 pathogenic M. kansasii isolates collected from patients with M. kansasii pulmonary disease in two tertiary medical centers in Taiwan between 2011 and 2022. Antimicrobial susceptibility testing was performed using Sensititre™ SLOMYCO1 or SLOMYCO2, and MIC breakpoints were according to CLSI 2018. We applied multivariate logistic regression and Cochran-Mantel-Haenszel test to assess the factors associated with drug resistance. Results: Most M. kansasii isolates in Taiwan remained susceptible to the first-line agents, including rifampin (92.2%) and clarithromycin (98.6%). High resistance rates were observed in ciprofloxacin (42.7%), doxycycline (56.2%), and trimethoprim/sulfamethoxazole (87.8%). The drug resistance rates of tested antibiotics for M. kansasii increased notably in 2018-2022 compared to those between 2015-2017. M. kansasii isolates from central Taiwan exhibited significantly higher resistance rates in all drugs compared to those in southern Taiwan. Pulmonary fibrocavitary lesion was an independent risk factor for resistance to rifampin and ciprofloxacin. Conclusions: The study reveals increasing resistance to the first- and second-line agents in M. kansasii isolates across Taiwan. Resistance epidemiology differed between regions. Fibrocavitary lung lesion was significantly associated with drug resistance. These findings underscore the importance of region-specific surveillance to undergo individualized treatment strategies for M. kansasii pulmonary disease.
| Type: | Article |
|---|---|
| Title: | The Resistance Trends in Mycobacterium kansasii Pulmonary Isolates and identification of risk factors for drug resistance in Taiwan |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jgar.2025.11.001 |
| Publisher version: | https://doi.org/10.1016/j.jgar.2025.11.001 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Mycobacterium kansasii, resistance, drug susceptibility, risk factor, Taiwan |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10217840 |
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