Bertoni, Damian;
Tsenkov, Maxim;
Magana, Paulyna;
Nair, Sreenath;
Pidruchna, Ivanna;
Querino Lima Afonso, Marcelo;
Midlik, Adam;
... Velankar, Sameer; + view all
(2025)
AlphaFold Protein Structure Database 2025: a redesigned interface and updated structural coverage.
Nucleic Acids Research
, Article gkaf1226. 10.1093/nar/gkaf1226.
(In press).
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Abstract
The AlphaFold Protein Structure Database (AFDB; https://alphafold.ebi.ac.uk), developed by EMBL-EBI and Google DeepMind, provides open access to hundreds of millions of high-accuracy protein structure predictions, transforming research in structural biology and the wider life sciences. Since its launch, AFDB has become a widely used bioinformatics resource, integrated into major databases, visualization platforms, and analysis pipelines. Here, we report the update of the database to align with the UniProt 2025_03 release, along with a comprehensive redesign of the entry page to enhance usability, accessibility, and structural interpretation. The new design integrates annotations directly with an interactive 3D viewer and introduces dedicated domains and summary tabs. Structural coverage has also been updated to include isoforms plus underlying multiple sequence alignments. Data are available through the website, FTP, Google Cloud, and updated APIs. Together, these advances reinforce AFDB as a sustainable resource for exploring protein sequence-structure relationships.
| Type: | Article |
|---|---|
| Title: | AlphaFold Protein Structure Database 2025: a redesigned interface and updated structural coverage |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/nar/gkaf1226 |
| Publisher version: | https://doi.org/10.1093/nar/gkaf1226 |
| Language: | English |
| Additional information: | © The Author(s) 2025. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10217839 |
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