Gordon, Siamon; Roberti, Annabell; Yona, Simon; Lin, Hsi-Hsien; (2025) F4/80, the plasma membrane antigen of mouse macrophages, an historic journey. Journal of Leukocyte Biology , 117 (9) , Article qiaf126. 10.1093/jleuko/qiaf126.

Text JLB-SUBMIT-S-25-00292 (1).pdf - Accepted Version Access restricted to UCL open access staff until 4 September 2026. Download (1MB)

Abstract

As its discovery nears a half century, the widespread use of F4/80 antigen as a differentiation marker of tissue macrophages of the mouse, continues to raise questions in and beyond experimental cellular immunology. Its structure as a 7 transmembrane G Protein-Coupled Receptor initiated the discovery of a diverse family of plasma membrane receptors. This review will trace milestones of research into the expression of F4/80, also known as Emr1, its value as a marker in formulation of the Mononuclear Phagocyte System and its function in a model of peripheral immune tolerance in the anterior chamber of the eye. Human EMR1 is closely related to a primate-restricted myeloid mechanoreceptor, EMR2, with a novel autocatalytic activation mechanism. We describe their relation to structurally related members of the group E adhesion GPCR subfamily and their contributions to homeostatic systems of the body through local plasma membrane cellular interactions.

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