DiFiglia, Marian;
Leavitt, Blair R;
Macdonald, Douglas;
Thompson, Leslie M;
(2024)
Towards Standardizing Nomenclature in Huntington's Disease Research.
Journal of Huntington's Disease
, 13
(2)
pp. 119-131.
10.3233/JHD-240044.
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Abstract
The field of Huntington's disease research covers many different scientific disciplines, from molecular biology all the way through to clinical practice, and as our understanding of the disease has progressed over the decades, a great deal of different terminology has accrued. The field is also renowned for its collaborative spirit and use of standardized reagents, assays, datasets, models, and clinical measures, so the use of standardized terms is especially important. We have set out to determine, through a consensus exercise involving basic and clinical scientists working in the field, the most appropriate language to use across disciplines. Nominally, this article will serve as the style guide for the Journal of Huntington's Disease (JHD), the only journal devoted exclusively to HD, and we lay out the preferred and standardized terminology and nomenclature for use in JHD publications. However, we hope that this article will also serve as a useful resource to the HD research community at large and that these recommended naming conventions will be adopted widely.
| Type: | Article |
|---|---|
| Title: | Towards Standardizing Nomenclature in Huntington's Disease Research |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3233/JHD-240044 |
| Publisher version: | https://doi.org/10.3233/jhd-240044 |
| Language: | English |
| Additional information: | © 2024 – The authors. Published by IOS Press. Creative Commons License (CC BY-NC 4.0) This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, Nomenclature, Huntington disease, HTT, mHTT, preclinical models, neuropathology, neuroanatomy, NEURONAL INTRANUCLEAR INCLUSIONS, AGE-OF-ONSET, MUTANT HUNTINGTIN, PROTEIN, POLYGLUTAMINE, NUCLEAR, MODEL, HD, VALIDATION, STRIATUM |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10217627 |
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