Peet, Connie;
Elmaraghi, Caroline;
Abdel-Aziz, Tarek;
Liang, Huang Hian;
Gains, Jennifer E;
Nguyen, Trung;
Wan, Simon;
... Gaze, Mark N; + view all
(2025)
Molecular radiotherapy for adult type metastatic neuroendocrine tumours in children.
European Journal of Nuclear Medicine and Molecular Imaging
, 52
(11)
pp. 4016-4024.
10.1007/s00259-025-07247-6.
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Abstract
Purpose: Paraganglioma, phaeochromocytoma and gastroenteropancreatic neuroendocrine tumours are rare in childhood. Molecular radiotherapy is one potential treatment for locally inoperable or metastatic disease. This study reviews the use and efficacy of molecular radiotherapy with both [<sup>131</sup>I] meta iodobenzylguanidine (mIBG) and [<sup>177</sup>Lu] DOTATATE in this patient group. Methods: This is an observational cohort study of all patients aged less than 18 years with adult type metastatic neuroendocrine cancers treated with molecular radiotherapy from 2003 to 2023 in one national referral centre. Results: Twelve patients, six male and six female, were treated. The median age at diagnosis was 12 years 3 months (range 7 years 11 months to 15 years 5 months), and at first molecular radiotherapy treatment was 13 years 7 months (range 8 years 8 months to 16 years 2 months). Nine had paraganglioma or phaeochromocytoma, three had other neuroendocrine tumours. Three received [<sup>177</sup>Lu] DOTATATE only, four received [<sup>131</sup>I] mIBG only, and five received both radiopharmaceuticals. Three patients had rapid disease progression and died within a year. Following initial treatment of the others, two had a complete response, four had a partial response, one had stable disease, and two had a mixed response. Nine patients remain alive, at a median of 5 years 0 months (range 2 years 4 months to 21 years 5 months) after start of treatment. Conclusion: Molecular radiotherapy can be beneficial, and may provide good disease control for long periods in a proportion of these patients. Combining different radiopharmaceuticals may be of value.
| Type: | Article |
|---|---|
| Title: | Molecular radiotherapy for adult type metastatic neuroendocrine tumours in children |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00259-025-07247-6 |
| Publisher version: | https://doi.org/10.1007/s00259-025-07247-6 |
| Language: | English |
| Additional information: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Radiology, Nuclear Medicine & Medical Imaging, Lutetium DOTATATE, Meta iodobenzylguanidine, Molecular radiotherapy, Neuroendocrine tumours, Paediatric, Phaeochromocytoma and paraganglioma, MALIGNANT PHEOCHROMOCYTOMA, YOUNG-ADULTS, PARAGANGLIOMAS, NEUROBLASTOMA, THERAPY, DISEASE, Y-90-DOTATOC, DIAGNOSIS, SURVIVAL |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10217358 |
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