Trapp, Stefan;
Skoug, Cecilia;
(2025)
Brain-derived GLP-1 – understanding the physiological function and anti-obesity potential of PreProGlucagon Neurons.
Endocrinology
, Article bqaf169. 10.1210/endocr/bqaf169.
(In press).
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Abstract
Glucagon-like Peptide-1 (GLP-1) is produced within the central nervous system by preproglucagon (PPG) neurons. This brain-derived GLP-1, rather than that released from the gut, is the physiological agonist for brain GLP-1 receptors. With brain GLP-1 receptors being a major target for eating suppression, understanding the physiology and the translational potential of PPG neurons is of pivotal importance, particularly since PPG neuron activation is also strongly associated with stress. This review critically summarizes the current knowledge of PPG neuron anatomy, physiology and molecular make-up together with insight into the relevant research tools, and consideration of the different PPG neuron populations within the CNS, in order to provide an appraisal of the potential of these neurons as drug targets and the associated risks and benefits.
| Type: | Article |
|---|---|
| Title: | Brain-derived GLP-1 – understanding the physiological function and anti-obesity potential of PreProGlucagon Neurons |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1210/endocr/bqaf169 |
| Publisher version: | https://doi.org/10.1210/endocr/bqaf169 |
| Language: | English |
| Additional information: | © The Author(s) 2025. Published by Oxford University Press on behalf of the Endocrine Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. See the journal About page for additional terms. |
| Keywords: | GCG, PPG, brainstem, food intake, obesity, transgenic |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10217328 |
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