Pressler, Ronit M;
(2025)
Diagnosis and classification of neonatal seizures.
Clinical Epileptology
, 38
(3)
pp. 195-202.
10.1007/s10309-025-00770-4.
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Abstract
Epileptic seizures are the most frequent neurological emergency in the neonatal period. In contrast to seizures in older children and adults they are mostly acute symptomatic seizures as a response to a prenatal or perinatal acute brain injury; less commonly epilepsy is already manifested in the neonatal period. Previous classifications systems were purely based on the clinical observation of behavior despite increasing evidence that the correct diagnosis based on the clinical symptoms is extremely unreliable. In 2021 the Neonatal Task Force of the International League against Epilepsy (ILAE) published a new classification system for neonatal seizures with implications for the clinical management of neonates with presumed or at risk of seizures. This classification emphasizes the importance of electroencephalography (EEG) or amplitude-integrated EEG (aEEG) in making the diagnosis and presumes a predominantly local onset of seizures in the neonatal period. Seizures are classified into motor (automatisms, clonic, epileptic spasms, myoclonic or tonic), nonmotor (autonomic or behavioral arrest), sequential or unclassifiable. Combining clinical observation with EEG or aEEG can help to determine the etiology and ultimately avoid overdiagnosis and underdiagnosis of neonatal seizures with the overall aim to improve the treatment and prognosis of seizures in neonates.
| Type: | Article |
|---|---|
| Title: | Diagnosis and classification of neonatal seizures |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s10309-025-00770-4 |
| Publisher version: | https://doi.org/10.1007/s10309-025-00770-4 |
| Language: | German |
| Additional information: | Dieser Artikel wird unter der Creative Commons Namensnennung 4.0 International Lizenz veröffentlicht, welche die Nutzung, Vervielfältigung, Bearbeitung, Verbreitung und Wiedergabe in jeglichem Medium und Format erlaubt, sofern Sie den/die ursprünglichen Autor(en) und die Quelle ordnungsgemäß nennen, einen Link zur Creative Commons Lizenz beifügen und angeben, ob Änderungen vorgenommen wurden. Die in diesem Artikel enthaltenen Bilder und sonstiges Drittmaterial unterliegen ebenfalls der genannten Creative Commons Lizenz, sofern sich aus der Abbildungslegende nichts anderes ergibt. Sofern das betreffende Material nicht unter der genannten Creative Commons Lizenz steht und die betreffende Handlung nicht nach gesetzlichen Vorschriften erlaubt ist, ist für die oben aufgeführten Weiterverwendungen des Materials die Einwilligung des jeweiligen Rechteinhabers einzuholen. Weitere Details zur Lizenz entnehmen Sie bitte der Lizenzinformation auf http://creativecommons.org/licenses/by/4.0/deed.de. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences & Neurology, Etiology, Electroencephalography, Epileptic seizures, Classification system, Prognosis, AMPLITUDE-INTEGRATED ELECTROENCEPHALOGRAPHY, EPILEPTIC SEIZURES, ELECTROGRAPHIC SEIZURES, INTERNATIONAL-LEAGUE, EEG, GUIDELINES, PROFILE, ILAE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10217218 |
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