Palix, Cassandre;
Chauveau, Lea;
Felisatti, Francesca;
Chocat, Anne;
Coulbault, Laurent;
Hebert, Oriane;
Mezenge, Florence;
... Medit-Ageing Research Group, .; + view all
(2025)
Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not β-accumulation in older adults: an exploratory study.
Frontiers in Aging Neuroscience
, 17
, Article 1508677. 10.3389/fnagi.2025.1508677.
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Abstract
Introduction: Allostatic load (AL) is a composite score of progressive physiological dysregulations in response to long-term exposure to everyday stress. Despite growing interest, limited research has focused on links with cerebral and cognitive aspects of aging and with markers sensitive to Alzheimer’s disease (AD) in a healthy elderly population and with a multimodal approach. / / Methods: At baseline, 111 older adults (without cognitive impairment) from the Age-Well trial completed blood and anthropometric markers collection, cognitive assessments and multimodal neuroimaging within 3 months. / / Results: AL was negatively associated with gray matter volume and white matter integrity within frontal and temporal regions and poorer attentional performance. / / Discussion: AL is linked to structural brain integrity in aging- and stress-sensitive regions but not with AD-related markers (β-amyloid load) and only in two AD-sensitive brain regions in older adults. These results highlight the potential interest of AL as a sensitive index of stress-induced brain aging.
| Type: | Article |
|---|---|
| Title: | Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not β-accumulation in older adults: an exploratory study |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnagi.2025.1508677 |
| Publisher version: | https://doi.org/10.3389/fnagi.2025.1508677 |
| Language: | English |
| Additional information: | Copyright © 2025 Palix, Chauveau, Felisatti, Chocat, Coulbault, Hébert, Mézenge, Landeau, Haudry, Fauvel, Collette, Klimecki, Marchant, De La Sayette, Vivien, Chételat, Poisnel and the Medit-Ageing Research Group. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | allostatic load, aging, Alzheimer’s disease, neuroimaging, cognition, stress, brain, amyloid |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry > Mental Health of Older People |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10216929 |
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