Mayor, Roberto;
(2025)
Forcing cell fate.
Nature Cell Biology
, 27
(10)
pp. 1594-1595.
10.1038/s41556-025-01775-x.
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Abstract
The transition of a pluripotent stem cell into a differentiated lineage is one of the most complex yet precisely orchestrated events in developmental biology. A study now reveals that mechanical and osmotic forces, long considered background players in guiding this transition, are essential regulators of chromatin accessibility and cell fate decisions.
| Type: | Article |
|---|---|
| Title: | Forcing cell fate |
| Location: | England |
| DOI: | 10.1038/s41556-025-01775-x |
| Publisher version: | https://doi.org/10.1038/s41556-025-01775-x |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10216632 |
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