Lorenzetti, Valentina;
McTavish, Eugene;
Thomson, Hannah;
Clemente, Adam;
Rendell, Peter;
Terrett, Gill;
Greenwood, Lisa-Marie;
... Manning, Victoria; + view all
(2025)
Brief mindfulness intervention for adults with cannabis use disorder: A Randomised Clinical Trial.
Drug and Alcohol Dependence
, Article 112909. 10.1016/j.drugalcdep.2025.112909.
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Abstract
Background: Cannabis use disorder (CUD) is characterised by strong cravings and an inability to reduce cannabis use despite experiencing adverse psychosocial outcomes. Brief, accessible, scalable, and low-cost interventions are needed to support people with a CUD. We investigated if a brief mindfulness-based intervention (MBI) reduces cannabis frequency, quantity and craving, compared to both an active and passive control conditions. Methods: A pre-registered, double-blind randomised control trial was run in in 66 adults (19 female) aged 18–56 with CUD reporting attempts to cut down or quit in the past 2 years, recruited from the general community (October 2019-July 2022). Participants were 1:1:1 allocated, to one of 3 interventions; MBI (n = 23), Relaxation (n = 21) or Control (n = 22) with a mean duration of 16 days, stratified by age and sex. All conditions included daily monitoring of usage. Baseline and follow-up in person testing occurred in Melbourne, Australia. The intervention occurred online. The primary outcome was change in cannabis use days (Δ follow-up minus baseline). Secondary outcomes were changes (Δ follow-up minus baseline) in: cannabis grams and craving (visual analogue scale; VAS), mindfulness (Five-Facet Mindfulness Questionnaire) and relaxation (VAS). We carried out intention-to-treat analysis. Results: There were no significant intervention-by-time effects on the primary outcome — cannabis frequency (F = 0.26, FDRp = .86)—nor on secondary outcomes: quantity, cravings, relaxation or mindfulness. Conclusion: Based on these findings a brief MBI does not appear to help people with CUD reduce their cannabis use.
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