Smith, Vanessa;
Denton, Christopher P;
Herrick, Ariane L;
Ittrich, Carina;
Alves, Margarida;
Cutolo, Maurizio;
(2025)
Nailfold capillaroscopy in patients with systemic sclerosis-associated interstitial lung disease: a substudy of the SENSCIS trial.
RMD Open: Rheumatic and Musculoskeletal Diseases
, 11
(4)
, Article e005704. 10.1136/rmdopen-2025-005704.
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Nailfold capillaroscopy in patients with systemic sclerosis-associated interstitial lung disease a substudy of the SENSCIS t.pdf - Published Version Download (1MB) | Preview |
Abstract
OBJECTIVE: To assess microvascular changes in nailfold capillaries in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD) who received nintedanib or placebo in a sub-study of the SENSCIS trial. METHODS: Nailfold capillaroscopy (NC) was performed at baseline and week 52. In the nintedanib and placebo groups, we measured capillary density (number of capillaries/mm), giant capillaries, abnormal shapes and percentage of fingers with microhaemorrhages. In addition, capillary density was evaluated in patients who did/did not have risk factors for rapid forced vital capacity (FVC) decline at baseline and who did/did not have ILD progression (absolute decline in FVC % predicted >5% or death) from baseline to week 52. RESULTS: Between baseline and week 52, no notable changes were observed in any NC measurement in the overall placebo or nintedanib groups. In patients with risk factors for rapid FVC decline (n=38), there was a numerical reduction in mean capillary density over 52 weeks with placebo, but it remained stable with nintedanib. Among patients who had ILD progression (n=11), there was a numerical increase in mean capillary density over 52 weeks with nintedanib, but it remained stable with placebo. There were no notable changes in capillary density among patients who did not have risk factors for rapid FVC decline at baseline or ILD progression at week 52. CONCLUSION: In a substudy of the SENSCIS trial, numerical differences in changes in capillary density assessed by NC over 52 weeks may suggest a potential effect of nintedanib in patients at risk of ILD progression.
| Type: | Article |
|---|---|
| Title: | Nailfold capillaroscopy in patients with systemic sclerosis-associated interstitial lung disease: a substudy of the SENSCIS trial |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/rmdopen-2025-005704 |
| Publisher version: | https://doi.org/10.1136/rmdopen-2025-005704 |
| Language: | English |
| Additional information: | © Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group |
| Keywords: | Autoimmune Diseases, Clinical Trial, Lung Diseases, Interstitial, Scleroderma, Systemic, Treatment, Humans, Microscopic Angioscopy, Male, Female, Scleroderma, Systemic, Middle Aged, Lung Diseases, Interstitial, Indoles, Capillaries, Nails, Aged, Disease Progression, Vital Capacity, Adult |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10216437 |
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