Jayaratne, Nirmitha;
Gianni, Alessandro;
Riding, Nathan;
Gati, Imaan;
Mehta, Shreeya;
Mamombe, Fortunate;
Nienaber, Christoph A;
(2025)
Exercise Recommendations for Patients with Marfan Syndrome: An updated review.
European Journal of Preventive Cardiology
, Article zwaf692. 10.1093/eurjpc/zwaf692.
(In press).
![[thumbnail of Exercise Recommendations for Patients with Marfan Syndrome - Accepted manuscript version.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/text.png) |
Text
Exercise Recommendations for Patients with Marfan Syndrome - Accepted manuscript version.pdf - Accepted Version Access restricted to UCL open access staff until 30 October 2026. Download (1MB) |
Abstract
Marfan syndrome (MFS) is a genetic connective tissue disorder which is inherited in an autosomal dominant manner. It is a multisystem disorder affecting the skeletal, ocular, pulmonary and cardiovascular systems. The cardiovascular complications such as aortic root dilatation and aortic dissection represent the most life-threatening of these and are the major causes of a reduced life-expectancy in Marfan patients compared to the general population. While exercise offers the general population several health benefits, particularly in reducing cardiovascular risks, in MFS it has long been considered a double-edged sword because of the condition’s unique pathology and exercise related cardiovascular risks. How much exercise is beneficial and how much is detrimental? Questions regarding optimal intensity, frequency, duration and type of exercise are still difficult to answer due to a lack of outcome studies in this area. The current guidelines for MFS and exercise are based on limited research. This review aims to explore and summarise the current evidence-based exercise recommendations for patients with MFS, the types of exercise they can safely engage in, and the key precautions to follow.
| Type: | Article |
|---|---|
| Title: | Exercise Recommendations for Patients with Marfan Syndrome: An updated review |
| DOI: | 10.1093/eurjpc/zwaf692 |
| Publisher version: | https://doi.org/10.1093/eurjpc/zwaf692 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Marfan syndrome, aortic aneurysm, aortic dissection, aortic rupture, FBN-1 gene, fibrillin-1, exercise, physical activity, exercise prescription |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10216417 |
Archive Staff Only
 |
View Item |
