Clapp, Lucie;
Giembycz, Mark;
Heinemann, Akos;
Jones, Robert L;
Narumiya, Shuh;
Norel, Xavier;
Sugimoto, Yukihiko;
... Yao, Chengcan; + view all
(2025)
Prostanoid receptors in GtoPdb v.2025.3.
IUPHAR/BPS Guide to Pharmacology CITE
, 2025
(3)
10.2218/gtopdb/f58/2025.3.
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Abstract
Prostanoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Prostanoid Receptors [709]) are activated by the endogenous ligands prostaglandins PGD2, PGE1, PGE2 , PGF2α, PGH2, prostacyclin [PGI2] and thromboxane A2. Differences and similarities between human and rodent prostanoid receptor orthologues, and their specific roles in pathophysiologic conditions are reviewed in [457]. Measurement of the potency of PGI2 and thromboxane A2 is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies.
| Type: | Article |
|---|---|
| Title: | Prostanoid receptors in GtoPdb v.2025.3 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2218/gtopdb/f58/2025.3 |
| Publisher version: | https://doi.org/10.2218/gtopdb/f58/2025.3 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10216153 |
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