Dong, H;
Reynolds, C;
Islam, S;
Sarkar, S;
Turner, S;
(2025)
Postprandial glycemic response in different ethnic groups in East London and its association with vitamin D status: Study protocol for an acute randomized crossover trial.
Nutrition and Health
10.1177/02601060251356528.
(In press).
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Abstract
BACKGROUND: In the UK, Black African-Caribbeans (ACs) and South Asians (SAs) have 3–6 times greater risks of developing type-2 diabetes mellitus (T2DM) and significantly higher prevalence of vitamin D (vitD) deficiency than White Caucasians. East London is among the areas with the highest prevalence of T2DM and the highest proportion of ethnic minority groups. This ethnic health inequality is ascribed to socioeconomic standing, dietary habits, culture, and attitudes, while biological diversity has rarely been investigated. AIM: The study aims to investigate the difference in the postprandial glycemic response (PGR), an independent risk factor of T2DM, between ethnic groups (White Caucasians, SAs, and ACs) in East London and its association with vitD status. METHODS: This acute randomized crossover trial will recruit healthy adults (n = 106) in East London between November 2023 and March 2025. Two test drinks are consumed by participants (a glucose drink containing 75 g glucose and pure orange juice) on different occasions. PGRs are monitored before and after drinking every 30 min for up to 2 h via finger prick. A fasting blood sample obtained via phlebotomy will be used for plasma 25(OH)D and relevant tests. A knowledge/perception questionnaire about vitD and a 4-day food diary (analyzing vitD dietary intake) will also be collected. Data will be analyzed using a multiple linear regression model adjusted by confounding factors (age, gender, body mass index, and body fat percentage). SUMMARY: The study results will be disseminated through journals and conferences, and target stakeholders.
| Type: | Article |
|---|---|
| Title: | Postprandial glycemic response in different ethnic groups in East London and its association with vitamin D status: Study protocol for an acute randomized crossover trial |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/02601060251356528 |
| Publisher version: | https://doi.org/10.1177/02601060251356528 |
| Language: | English |
| Additional information: | This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| Keywords: | Postprandial glycemia, type 2 diabetes, oral glucose tolerance test, 25(OH)D, ethnic minority, body fat percentage, body mass index |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10216151 |
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