Gerstmann, Katrin;
Jurčić, Nina;
Blasco, Edith;
Kunz, Severine;
de Almeida Sassi, Felipe;
Wanaverbecq, Nicolas;
Zampieri, Niccolò;
(2022)
The role of intraspinal sensory neurons in the control of quadrupedal locomotion.
Current Biology
, 32
(11)
2442-2453.e4.
10.1016/j.cub.2022.04.019.
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Abstract
From swimming to walking and flying, animals have evolved specific locomotor strategies to thrive in different habitats. All types of locomotion depend on the integration of motor commands and sensory information to generate precisely coordinated movements. Cerebrospinal-fluid-contacting neurons (CSF-cN) constitute a vertebrate sensory system that monitors CSF composition and flow. In fish, CSF-cN modulate swimming activity in response to changes in pH and bending of the spinal cord; however, their role in mammals remains unknown. We used mouse genetics to study their function in quadrupedal locomotion. We found that CSF-cN are directly integrated into spinal motor circuits. The perturbation of CSF-cN function does not affect general motor activity nor the generation of locomotor rhythm and pattern but results in specific defects in skilled movements. These results identify a role for mouse CSF-cN in adaptive motor control and indicate that this sensory system evolved a novel function to accommodate the biomechanical requirements of limb-based locomotion.
| Type: | Article |
|---|---|
| Title: | The role of intraspinal sensory neurons in the control of quadrupedal locomotion |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cub.2022.04.019 |
| Publisher version: | https://doi.org/10.1016/j.cub.2022.04.019 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. Articles published under an Elsevier user license are protected by copyright. Users may access, download, copy, translate, text and data mine (but may not redistribute, display or adapt) the articles for non-commercial purposes. https://www.elsevier.com/about/policies-and-standards/open-access-licenses/elsevier-user |
| Keywords: | CSF-contacting neurons, spinal circuits, motor control, Pkd2l1, interoception, sensorimotor integration |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10216095 |
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