Datta, Soumitra;
Sharma, Varuna;
Mukherjee, Arnab;
Agrawal, Sanjit;
Sirohi, Bhawna;
Gyawali, Bishal;
(2025)
Qualitative study of oncologists’ perceptions on the US Food and Drug
Administration approval status and
clinical practice guidelines and their
impact on local practice patterns in India.
BMJ Oncology
, 4
(1)
, Article e000863. 10.1136/bmjonc-2025-000863.
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Abstract
Objective: How the US Food and Drug Administration (FDA) approval status and international cancer care guidelines influence the practice of oncology in low-and-middle-income countries like India has not been studied so far. We aimed to study how oncologists in India perceive drug approval status and guideline recommendations for their own clinical practice. // Methods and analysis: The study followed qualitative research design, incorporating semistructured interviews. The participants were qualified medical oncologists in India representing a wide range of geographical regions, including East, West, North and Southern India. Data were collected using a semistructured interview schedule. In-depth qualitative interviews were undertaken, and all interviews were transcribed verbatim. Data analysis followed the principles of thematic analysis to generate themes. // Results: Of the 25 medical oncologists interviewed for this study, 15 (60%) showed awareness of the limitations of the US FDA approval, including those of accelerated approval and approvals based on phase 2 trials. They also expressed disappointment about the lack of availability and affordability of cancer drugs and wished for more representation of Indian patients in the pivotal trials leading to the US FDA approval. NCCN guidelines were the most used guidelines and participants showed strong support for local institutional guidelines. However, participants felt that resource-stratified guidelines from different societies were not very helpful. // Conclusions: Oncologists in India demonstrated awareness of the limitations of the US FDA drug approvals and found resource-stratified guidelines to be unhelpful. They preferred the main guidelines and institutional protocols over resource-stratified guidelines.
| Type: | Article |
|---|---|
| Title: | Qualitative study of oncologists’ perceptions on the US Food and Drug Administration approval status and clinical practice guidelines and their impact on local practice patterns in India |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/bmjonc-2025-000863 |
| Publisher version: | https://doi.org/10.1136/bmjonc-2025-000863 |
| Language: | English |
| Additional information: | Copyright © Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC,https://creativecommons.org/licenses/by-nc/4.0/. No commercial re-use. See rights and permissions. Published by BMJ Group. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10215963 |
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