Goodwin, Elizabeth;
Heather, Amy;
Morrish, Nia;
Freeman, Jenny;
Boddy, Kate;
Thomas, Sarah;
Chataway, Jeremy;
... Hawton, Annie; + view all
(2025)
Comparative Responsiveness of Preference-Based Health-Related Quality of Life, Social Care and Wellbeing Measures in the Context of Multiple Sclerosis.
Value Health
10.1016/j.jval.2025.09.3063.
(In press).
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Abstract
OBJECTIVES: To provide evidence on the responsiveness of social care and wellbeing preference-based measures (PBMs) compared to health-related quality of life PBMs in the context of multiple sclerosis (MS). METHODS: The ICEpop CAPability measure for Adults (ICECAP-A) and Adult Social Care Outcomes Toolkit (ASCOT) were completed online in September 2019, March 2020, September 2020, via the UK MS Register. Responses were linked to EQ-5D-3L and MS Impact Scale-Eight Dimensions (MSIS-8D) values, and to MS Walking Scale-12 (MSWS-12), Hospital Anxiety and Depression Scale (HADS) and Fatigue Severity Scale (FSS) scores. Responsiveness was assessed in relation to minimal important differences on MSWS-12, HADS and FSS between timepoints, using mean change scores, t-tests, standardised effect sizes, standardised response means and multivariable regression analyses. RESULTS: Data from 1,742 people with MS were available for analysis. When using standardised values, MSIS-8D showed the greatest responsiveness and EQ-5D-3L the least. In contrast, when absolute utility values were used, EQ-5D-3L performed similarly to MSIS-8D and better than ICECAP-A and ASCOT. Standardised regression analyses indicated the MSIS-8Ds to be the most responsive, followed by the ASCOT, ICECAP-A, and EQ-5D-3L. CONCLUSIONS: The ICECAP-A, ASCOT and MSIS-8D were more responsive than the EQ-5D-3L in the context of MS when compared using standardised scores. The increased responsiveness of EQ-5D-3L when absolute values were used seems an artefact of the wide-ranging scale of this measure. This illustrates how the maximum potential range of values for a given PBM tariff could influence whether an intervention is found to be cost-effective.
| Type: | Article |
|---|---|
| Title: | Comparative Responsiveness of Preference-Based Health-Related Quality of Life, Social Care and Wellbeing Measures in the Context of Multiple Sclerosis |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jval.2025.09.3063 |
| Publisher version: | https://doi.org/10.1016/j.jval.2025.09.3063 |
| Language: | English |
| Additional information: | © 2025 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| Keywords: | EQ-5D, Health-related quality of life measures, Preference-based measures, QALY measures, Responsiveness, Social care related quality of life measures, Wellbeing measures |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10215937 |
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