Zurfluh, Leon;
Callejas, Antonio;
Gomez, Antonio Jesus;
(2025)
Thermally induced changes in the elastic properties of prostatic tissue: a preliminary study onex vivobovine samples.
Physics in Medicine & Biology
10.1088/1361-6560/ae1181.
(In press).
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Abstract
OBJECTIVE: To characterise the thermally induced changes in the elastic properties of prostatic tissue and investigate their correlation with thermal dose. APPROACH: Ex vivo bovine prostate samples were subjected to three heating protocols-constant-rate heating, steady-state temperature, and steady-state temperature followed by rapid cooling. Acoustic Radiation Force-based Shear Wave Elastography was used to monitor shear wave speed (SWS), and the results were interpreted in relation to thermal dose using the cumulative equivalent minutes at 43°C (CEM43) scale. MAIN RESULTS: Thermal exposure consistently resulted in increased SWS, with increments of up to five-fold observed at temperatures above 60°C in the constant-rate heating tests. Irreversible changes were also observed in the steady-state temperature test followed by rapid cooling even at thermal exposures as low as 20 CEM43 minutes. SIGNIFICANCE: These findings support the potential of elastography to delineate thermally ablated regions in prostate cancer treatment and encourages further investigation on the potential of SWS to serve as a biomarker of thermal dose.
| Type: | Article |
|---|---|
| Title: | Thermally induced changes in the elastic properties of prostatic tissue: a preliminary study onex vivobovine samples |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1088/1361-6560/ae1181 |
| Publisher version: | https://doi.org/10.1088/1361-6560/ae1181 |
| Language: | English |
| Additional information: | As the Version of Record of this article is going to be / has been published on a gold open access basis under a CC BY 4.0 licence, this Accepted Manuscript is available for reuse under a CC BY 4.0 licence immediately (https://creativecommons.org/licences/by/4.0). |
| Keywords: | Elasticity change, Prostate, Shear Wave Elastography, Thermal ablation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10215600 |
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