Luo, Shicui;
Yang, Qiuqiong;
Williams, Gareth R;
Wang, Fengyu;
Jia, Yamin;
Chen, Wenlin;
Zhao, Huanhuan;
... Wu, Junzi; + view all
(2025)
Flavonoid-containing copolymers can act as both extended-release excipients and active pharmaceutical ingredients for the treatment of diabetes.
Materials & Design
, 258
, Article 114673. 10.1016/j.matdes.2025.114673.
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Abstract
This study focuses on multifaceted applications of plant-based natural products in the treatment of diabetes, specifically aiming to use flavonoids as both active ingredients and extended-release excipients for drug delivery. Three flavonoids (Chrysin, Biochanin A and Gardenin B) were acrylated and subsequently block copolymerised with 3-acrylamido phenyl boronic acid (AAPBA) to yield p(AAPBA-b-Chrysin), p(AAPBA-b-BiochaninA) and p(AAPBA-b-Gardenin B), collectively referred to as p(AAPBA-b-acrylic acid flavone) nanoparticles (NPs). The polymers were next formulated into NPs, and their stability, pH-responsiveness and glucose sensitivity were evaluated. These NPs can be loaded with insulin and have sustained-release properties, with insulin release being accelerated in the presence of glucose. The cytocompatibility of p(AAPBA-b-acrylic acid flavone) NPs was confirmed via cytotoxicity tests in vitro, which revealed that they were mainly accumulated in the liver and kidneys 24 h after injection. In a diabetic mouse model, these NPs were shown to reduce blood sugar levels in the long term; protect liver, kidney and heart function; reduce inflammatory factor levels; and balance oxidative capacity. Therefore, our flavonoid-based NPs can serve as efficient drug delivery systems for the treatment of diabetes.
| Type: | Article |
|---|---|
| Title: | Flavonoid-containing copolymers can act as both extended-release excipients and active pharmaceutical ingredients for the treatment of diabetes |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.matdes.2025.114673 |
| Publisher version: | https://doi.org/10.1016/j.matdes.2025.114673 |
| Language: | English |
| Additional information: | © 2025 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Flavonoids, Extended-release excipients, Active pharmaceutical ingredients, Diabetes, Nanoparticles |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10215362 |
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