Saiardi, Adolfo;
Jessen, Henning J;
Fiedler, Dorothea;
(2025)
Enabling Technologies for the Dissection of Inositol Pyrophosphate Physiology.
Methods in Molecular Biology
, 2972
pp. 1-18.
10.1007/978-1-0716-4799-8_1.
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Abstract
The diverse chemical structures of inositol pyrophosphates attract growing interest toward this class of small molecule messengers. However, their highly charged nature, the lack of a chromophore or a fluorophore, their close structural relatedness, and the complexity of their metabolism pose serious challenges to inositol pyrophosphates studies. Here, we summarize how researchers have begun to overcome these challenges and how recent experimental advances are propelling inositol pyrophosphate research into the future.
| Type: | Article |
|---|---|
| Title: | Enabling Technologies for the Dissection of Inositol Pyrophosphate Physiology |
| Location: | United States |
| DOI: | 10.1007/978-1-0716-4799-8_1 |
| Publisher version: | https://doi.org/10.1007/978-1-0716-4799-8_1 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Allosteric binding, Capillary electrophoresis, Experimental model, Historical perspective, Liquid chromatography, Mass spectrometry, Metabolism, Nuclear magnetic resonance, Pyrophosphorylation, Signaling |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10215060 |
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