Wang, Shuming;
Xu, Nuo;
Wang, Wenwen;
He, Yongxiang;
Yang, Yuqian;
Zhang, Liuning;
Zou, Yanping;
... Xiao, Lin; + view all
(2025)
Forelimb Motor Learning and Memory Consolidation Drives Distinct Oligodendrocyte Plasticity to Regulate Task-related Neuronal Activity.
Advanced Science
, Article e05367. 10.1002/advs.202505367.
(In press).
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Abstract
Motor learning induces oligodendrocyte (OL) dynamics/plasticity during learning. However, it remains unclear whether different adaptive OL dynamics are required for different phases of motor learning and how they regulate neuronal activity. Here, reduced oligodendrogenesis accompanied is showed by elongated node length in the contra-rostral forelimb area (cRFA) motor cortex during learning of the forelimb reaching task, both of which correlate with the learning performance. However, this is observed that increased oligodendrogenesis during the motor memory consolidation phase, which also correlates with the motor skill maintenance. Strikingly, Myrf conditional knockout (OPC-Myrf-cKO) mice, in which oligodendrogenesis can be artificially blocked, showed improved learning performance along with increased node length and increased task-related neuronal activity in the cRFA when Myrf deletion (i.e., oligodendrogenesis blockade) is introduced prior to learning. However, they showed impaired rehearsal performance accompanied by decreased task-related neuronal activity when gene deletion is induced after learning. These findings suggest that motor learning and consolidation may drive distinct OL plasticity to fine-tune task-related neuronal activity required at different phases.
| Type: | Article |
|---|---|
| Title: | Forelimb Motor Learning and Memory Consolidation Drives Distinct Oligodendrocyte Plasticity to Regulate Task-related Neuronal Activity |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/advs.202505367 |
| Publisher version: | https://doi.org/10.1002/advs.202505367 |
| Language: | English |
| Additional information: | © 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | adaptive OL/myelin plasticity, calcium activity, memory consolidation, motor learning, single pellet reaching task |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10214879 |
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