Chen, Hongyi;
Cheng, Rui;
Chung, Se Hun;
Marghoub, Arsalan;
Zhong, Hui;
Fang, Guohao;
Balabani, Stavroula;
... Huang, Jie; + view all
(2025)
Direct ink writing of bioactive PCL/laponite bone Implants: Engineering the interplay of design, process, structure, and function.
Biomedical Technology
, 11
, Article 100101. 10.1016/j.bmt.2025.100101.
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Abstract
Direct ink writing (DIW) is a room-temperature extrusion-based 3D printing technique that enables the fabrication of dense, customizable implants from viscous inks with precise spatial control. In this study, we present an engineering design framework for DIW-printed PCL/Laponite composites by tuning ink formulations and printing orientations to systematically investigate and control the complex interplay between shape fidelity, mechanical performance, and cellular response. Our findings show that printing at 0° orientation enhances filament-aligned surface topographies, which guide osteoblast attachment and significantly promote cell proliferation and mineralization. In contrast to previous studies using fused deposition modeling (FDM), we observe that printing at 90° orientation (perpendicular to the tensile load direction) results in higher mechanical performance due to improved filament bonding. Increasing Laponite loading (up to 30 %) improves shape retention by increasing ink viscosity, raises Young's modulus by up to 110 %, and enhances surface bioactivity by introducing hydrophilic and bioactive cues. This study provides a tunable strategy for engineering bioactive and surface-active implants for the clinical need for non-load-bearing orthopaedic applications where structural integrity, surface-mediated osteointegration, and customized geometry are clinically essential.
| Type: | Article |
|---|---|
| Title: | Direct ink writing of bioactive PCL/laponite bone Implants: Engineering the interplay of design, process, structure, and function |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.bmt.2025.100101 |
| Publisher version: | https://doi.org/10.1016/j.bmt.2025.100101 |
| Language: | English |
| Additional information: | © 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | 3D printing, Mechanical properties, 3D assessment, Micro-CT, Cell activities |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10214631 |
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