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A call for deeper insights into intramural pregnancy: An international data registry

Nijjar, Simrit; Bottomley, Cecilia; Jurkovic, Davor; (2025) A call for deeper insights into intramural pregnancy: An international data registry. Acta Obstetricia et Gynecologica Scandinavica , 104 (8) pp. 1420-1423. 10.1111/aogs.70007. Green open access

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Abstract

Intramural pregnancy (IMP) is a rare and potentially life-threatening uterine ectopic pregnancy implanted within the myometrium. Despite its recognition as a distinct clinical entity, diagnostic challenges and a lack of standardized management protocols persist. IMP occurs when a gestational sac implants into the myometrium beyond the endometrial-myometrial junction, often following uterine trauma. Diagnosis is hindered by non-specific symptoms and frequent misclassification. While ultrasound is the primary diagnostic tool, magnetic resonance imaging (MRI) may be needed in unclear cases. Treatment options range from expectant management to surgical intervention, but no consensus exists on the optimal approach. To enhance understanding and improve clinical outcomes, we propose an international IMP registry to collect data on diagnosis, treatment, and fertility outcomes. This collaborative effort aims to inform evidence-based guidelines, facilitating accurate early diagnosis and optimized patient care.

Type: Article
Title: A call for deeper insights into intramural pregnancy: An international data registry
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/aogs.70007
Publisher version: https://doi.org/10.1111/aogs.70007
Language: English
Additional information: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. © 2025 The Author(s). Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).
Keywords: Science & Technology, Life Sciences & Biomedicine, Obstetrics & Gynecology, diagnosis, international registry, intramural pregnancy, treatment, uterine ectopic pregnancy, ECTOPIC PREGNANCY, MANAGEMENT, DIAGNOSIS
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Reproductive Health
URI: https://discovery.ucl.ac.uk/id/eprint/10214257
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