Halstead, S; Yap, CX; Warren, N; Agarwal, SM; Brand, BA; Chan, SKW; Cipriani, A; ... Pillinger, T; + view all Halstead, S; Yap, CX; Warren, N; Agarwal, SM; Brand, BA; Chan, SKW; Cipriani, A; Correll, CU; Crossley, N; D'Ambrosio, E; Emsley, R; Firth, J; Gaughran, F; Gee, S; Hahn, M; Hayes, JF; Heald, A; Howes, OD; Kane, JM; Kapi, M; Leucht, S; Meyer, N; O'Donoghue, B; Okeke, E; Perry, BI; Solmi, M; Sommer, IE; Srivastava, V; Taipale, H; Taylor, D; Tiihonen, J; Young, AH; Firth, J; Siddiqi, N; Siskind, D; Rosenbaum, S; Galletly, C; Allan, S; Caneo, C; Carney, R; Carvalho, AF; Chatterton, ML; Correll, CU; Curtis, J; Gaughran, F; Heald, A; Hoare, E; Jackson, SE; Kisely, S; Lovell, K; McGorry, PD; Mihalopoulos, C; O'Donoghue, B; Pillinger, T; Sarris, J; Schuch, FB; Shiers, D; Smith, L; Solmi, M; Suetani, S; Taylor, J; Teasdale, SB; Thornicroft, G; Torous, J; Usherwood, T; Vancampfort, D; Veronese, N; Ward, PB; Yung, AR; Killackey, E; Stubbs, B; McCutcheon, RA; Siskind, D; Pillinger, T; - view fewer (2025) Holistic prevention and management of physical health side-effects of psychotropic medication: second report of the Lancet Psychiatry Physical Health Commission. The Lancet Psychiatry , 12 (9) pp. 673-699. 10.1016/S2215-0366(25)00162-2.

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Abstract

Executive summary: Background: To counter modern medicine's tendency to fragment health care into silos, people with mental illness should have access to holistic care that protects both physical and mental health. Antipsychotics, mood stabilisers, and antidepressants are an integral component of evidenced-based treatment for mental disorders, and reduce morbidity and mortality at a population level. However, the various medications within these classes of psychotropic drugs lead to a range of important side-effects across multiple physiological systems. Side-effects can impact physical health and quality of life and lead to non-adherence, compromising the associated benefits of treatment.

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