Feng, Jiangqi;
(2025)
Phosphorylcholine Polymersomes Treating Chronic Inflammation.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
PMPC-PDPA polymersomes have universal anti-inflammatory effects and could play an antiinflammatory role in acute and chronic inflammation. Especially in the treatment of local inflammation and inflammation-induced fibrosis. Macrophages, abundant in inflammatory sites, could take up PMPC-PDPA polymersomes. This process is related to the CD36, SR-B1 and CD81 expressed on the surface of macrophages. Additionally, PMPC-PDPA polymersomes can selectively accumulate in inflammatory lesions and inhibit the NF-κB pathway in activated macrophages. Finally, it reduces the secretion of proinflammatory cytokines. Most importantly,. PMPC-PDPA polymersomes have also been considered as a multi-functional drug delivery system that can achieve synergistic therapeutic effects, capable of serving as dual-functional nanoparticles as drug delivery vehicles and therapeutic agents. We demonstrate that pHresponsive PMPC-PDPA polymersomes can enhance the anti-inflammatory capacity of loaded anti-inflammatory drugs and have the potential to promote inflammation resolution themselves. It is reasonable to assume that PMPC-PDPA polymersomes might be used as a novel anti-inflammatory drug delivery system to treat inflammatory diseases like acute pancreatitis and pulmonary fibrosis.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Phosphorylcholine Polymersomes Treating Chronic Inflammation |
| Language: | English |
| Additional information: | Copyright © The Author 2025. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10214229 |
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