Teh, Irvin;
Moulin, Kévin;
Ferreira, Pedro F;
Absil, Julie;
Afzali, Maryam;
Agger, Peter;
Akbari, Behnaz;
... Stoeck, Christian T; + view all
(2025)
Multi-centre Investigation of Cardiac Diffusion Tensor Imaging in Healthy Volunteers by SCMR Cardiac Diffusion Special Interest Group NETwork (SIGNET).
Journal of Cardiovascular Magnetic Resonance
, Article 101948. 10.1016/j.jocmr.2025.101948.
(In press).
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Abstract
BACKGROUND: Cardiac diffusion tensor imaging (cDTI) is an emerging technique for microstructural characterization of the heart and has shown clinical potential in a range of cardiomyopathies. However, there is substantial variation reported for in vivo cDTI results across the literature, and sensitivity of cDTI to differences in imaging sites, scanners, acquisition protocols and post-processing methods remains incompletely understood. METHODS: SIGNET is a prospective multi-centre, observational study in travelling and non-travelling healthy volunteers. The study was initiated by the executive board of the SCMR Cardiac Diffusion Special Interest Group (SIG) as a follow up to a previous multi-centre study on phantom validation of cardiac DTI and a recently published SCMR consensus statement on cardiac diffusion MRI. The study has been developed by the Project Management Committee in consultation with the SCMR Cardiac Diffusion SIG, which includes international experts in cardiac diffusion MRI. To date, more than 20 international institutions have engaged with the study, including sites that are new to cardiac DTI, making this the largest collaborative effort in the field. DISCUSSION: SIGNET will provide important information about the key sources of variation in cardiac DTI. This will help rationalise strategies for addressing and minimising such variation. Harmonisation of protocols in this and future studies will underpin efforts to translate cardiac DTI for clinical application.
| Type: | Article |
|---|---|
| Title: | Multi-centre Investigation of Cardiac Diffusion Tensor Imaging in Healthy Volunteers by SCMR Cardiac Diffusion Special Interest Group NETwork (SIGNET) |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jocmr.2025.101948 |
| Publisher version: | https://doi.org/10.1016/j.jocmr.2025.101948 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Cardiac DTI, heart, inter-site variation, intra-site variation, myocardium, pulse sequence development, tissue characterisation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10214070 |
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