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Importance of Aligning Training Strategy with Evaluation for Diffusion Models in 3D Multiclass Segmentation

Fu, Yunguan; Li, Yiwen; Saeed, Shaheer U; Clarkson, Matthew J; Hu, Yipeng; (2024) Importance of Aligning Training Strategy with Evaluation for Diffusion Models in 3D Multiclass Segmentation. In: Mukhopadhyay, A and Oksuz, I and Engelhardt, S and Zhu, D and Yuan, Y, (eds.) Deep Generative Models (DGM4MICCAI 2023). (pp. pp. 86-95). Springer Green open access

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Abstract

Recently, denoising diffusion probabilistic models (DDPM) have been applied to image segmentation by generating segmentation masks conditioned on images, while the applications were mainly limited to 2D networks without exploiting potential benefits from the 3D formulation. In this work, we studied the DDPM-based segmentation model for 3D multiclass segmentation on two large multiclass data sets (prostate MR and abdominal CT). We observed that the difference between training and test methods led to inferior performance for existing DDPM methods. To mitigate the inconsistency, we proposed a recycling method which generated corrupted masks based on the model’s prediction at a previous time step instead of using ground truth. The proposed method achieved statistically significantly improved performance compared to existing DDPMs, independent of a number of other techniques for reducing train-test discrepancy, including performing mask prediction, using Dice loss, and reducing the number of diffusion time steps during training. The performance of diffusion models was also competitive and visually similar to non-diffusion-based U-net, within the same compute budget. The JAX-based diffusion framework has been released at https://github.com/mathpluscode/ImgX-DiffSeg.

Type: Proceedings paper
Title: Importance of Aligning Training Strategy with Evaluation for Diffusion Models in 3D Multiclass Segmentation
Event: 3rd Workshop on Deep Generative Models for Medical Image Computing and Computer Assisted Intervention (DGM4MICCAI) at the 26th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI)
Location: CANADA, Vancouver
Dates: 8 Oct 2023
ISBN-13: 978-3-031-53766-0
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-3-031-53767-7_9
Publisher version: https://doi.org/10.1007/978-3-031-53767-7_9
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Abdominal CT, Computer Science, Computer Science, Artificial Intelligence, Computer Science, Theory & Methods, Diffusion Model, Image Segmentation, Prostate MR, Science & Technology, Technology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10214039
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