Anson, Matthew;
Henney, Alex E;
Edwards, Harry;
Ibarburu, Gema H;
Mordi, Ify;
Jaffar, Shabbar;
Garrib, Anupam;
... Alam, Uazman; + view all
(2025)
The rapidly increasing incidence of type 2 diabetes and macrovascular and microvascular complications disproportionately affects younger age groups: A decade of evidence from an international federated database.
Diabetes Research and Clinical Practice
, 228
, Article 112431. 10.1016/j.diabres.2025.112431.
(In press).
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Abstract
Aims: To characterise recent trends in incidence and prevalence of type 2 diabetes (T2D) associated complications, and their relative impact across the lifespan. Methods: We conducted a retrospective cohort study using the TriNetX global federated database. Incidence and prevalence of T2D and associated complications: ischaemic heart disease (IHD), heart failure, cerebral infarction, neuropathy, nephropathy, and retinopathy were assessed between 2012 and 2023. Incidence odds ratios (IOR) were calculated by age group. Results: 7,918,666 individuals had T2D. The IOR (95 % CI), comparing individuals aged ≥ 85 years to < 35 years decreased for all complications from 2012 to 2023: IHD [IOR 6.82, (6.40, 7.26) to IOR 2.27 (2.17, 2.38)], heart failure [IOR 5.38, (5.03, 5.75) to IOR 1.80 (1.72, 1.89)], cerebral infarction [IOR 3.06, (2.76, 3.40) to IOR 1.45 (1.34, 1.57)], neuropathy [IOR 0.84, (0.74, 0.95) to IOR 0.47 (0.44, 0.49)], nephropathy [IOR 1.14, (1.03, 1.27) to IOR 0.90 (0.87, 0.94)] and retinopathy [IOR 0.56, (0.50, 0.63) to IOR 0.27 (0.25, 0.29)]. Conclusions: Rising rates of T2D associated complications in younger adults signal an emerging epidemic of early-onset comorbidity with substantial lifetime burden. These findings emphasise the urgent need for earlier detection, aggressive risk factor management, and targeted prevention strategies in younger populations.
| Type: | Article |
|---|---|
| Title: | The rapidly increasing incidence of type 2 diabetes and macrovascular and microvascular complications disproportionately affects younger age groups: A decade of evidence from an international federated database |
| Location: | Ireland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.diabres.2025.112431 |
| Publisher version: | https://doi.org/10.1016/j.diabres.2025.112431 |
| Language: | English |
| Additional information: | © 2025 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, Type 2 diabetes, Epidemiology, Microvascular, Macrovascular, RISK-FACTORS, CARDIOVASCULAR-DISEASE, ADULTS, TRENDS, US, EPIDEMIOLOGY, PREVALENCE, MORTALITY, PEOPLE, ONSET |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10214002 |
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