Barry, Charlotte;
(2025)
Identifying Posttraumatic Stress Disorder Symptom Profiles and Their
Impact on Psychological Treatment Outcomes in Primary Care: A Latent
Profile Analysis.
Doctoral thesis (D.Clin.Psy), UCL (University College London).
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Abstract
Background: Posttraumatic Stress Disorder (PTSD) poses a significant public health challenge. Veterans are disproportionately affected, with PTSD prevalence rates significantly higher compared to the general population. Despite the availability of evidence-based treatments, not all veterans respond to treatments, highlighting the need to explore factors that may account for this, including diverse symptom presentations. Aims: This review synthesised the literature on distinct PTSD symptom subtypes in veterans using a data-driven hierarchical clustering approach. Methods: The review was registered with PROSPERO (CRD42024541234). A systematic search of MEDLINE and PsycINFO was completed on July 5th, 2024, using terms related to PTSD, military populations, and latent class/profile analysis. Eligible studies used LCA or LPA to identify PTSD subtypes in adult veterans with PTSD. Hierarchical clustering was used to synthesise symptom profiles. Results: Six studies involving 5,544 veterans met the inclusion criteria. From the studies reviewed, 23 profiles of PTSD symptoms were identified. Through hierarchical cluster analysis, four distinct PTSD symptom clusters were determined: (1) low symptom severity, (2) high symptoms with elevated arousal and hypervigilance, (3) moderate severity and (4) moderate severity with high emotional dysregulation and cognitive difficulties. Implications: These findings provide a framework for understanding PTSD heterogeneity in veterans and support future research into tailored clinical interventions. Symptom clusters, particularly those emphasising emotional dysregulation, highlight the need for personalised treatment strategies. Future research should prioritise standardised research methods and culturally diverse populations to improve outcomes for veterans with PTSD.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | D.Clin.Psy |
| Title: | Identifying Posttraumatic Stress Disorder Symptom Profiles and Their Impact on Psychological Treatment Outcomes in Primary Care: A Latent Profile Analysis |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2025. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10213464 |
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