Molvik, Inger;
Strand, Bjørn Heine;
Rokstad, Anne Marie Mork;
Aakhus, Eivind;
Aam, Stina;
Bergh, Sverre;
Brækhus, Anne;
... Selbæk, Geir; + view all
(2025)
Incidence of dementia among individuals 70 years and older in Norway: A HUNT study.
Journal of Alzheimer's Disease
10.1177/13872877251371242.
(In press).
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Abstract
Background: With increasing population longevity, Alzheimer's disease and dementia have become a health priority, and high-quality incidence estimates are needed. / Objective: To provide reliable and precise incidence estimates of dementia applying a population-based sample of individuals aged 70+. / Methods: A longitudinal cohort design was used, with baseline assessment in the Norwegian HUNT4 70+ study (2017–19) and at follow-up four years later (2021–23). Age-specific dementia incidence rates, standardized for the Norwegian population, were calculated as the number of new dementia cases per 1000 person-years assuming onset midway between study waves with inverse probability weights based on baseline factors associated with non-participation or death. / Results: Among 5229 dementia-free individuals at baseline, 749 developed dementia over a 4.2-year period, resulting in a cumulative incidence proportion of 14.3%. At follow-up, 33.8% of new dementia cases showed no baseline cognitive impairment, while the rest had mild cognitive impairment (MCI). Of those with baseline MCI, 25.5% reverted to normal cognition, 48.2% remained MCI, and 26.2% developed dementia. The dementia incidence per 1000 person-years, was 43.9 (95% confidence interval (CI) 40.8, 47.1) (weighted for non-response and standardized to the dementia-free Norwegian population). / Conclusions: Our study found higher dementia incidence rates in the 70+ population than hospital records indicate. Most individuals had preceding MCI, with similar numbers reverting to normal cognition as developing dementia. The projected incident dementia cases suggest a near doubling between 2023 and 2050, significantly impacting families and healthcare planning, including early detection and interventions.
| Type: | Article |
|---|---|
| Title: | Incidence of dementia among individuals 70 years and older in Norway: A HUNT study |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/13872877251371242 |
| Publisher version: | https://doi.org/10.1177/13872877251371242 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Alzheimer’s disease, dementia, epidemiology, incidence, population study |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10213443 |
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