Burton-Murray, Helen;
Sella, Aluma Chovel;
Gydus, Julia E;
Atkins, Micaela;
Palmer, Lilian P;
Kuhnle, Megan C;
Becker, Kendra R;
... Lawson, Elizabeth A; + view all
(2024)
Medical Comorbidities, Nutritional Markers, and Cardiovascular Risk Markers in Youth With ARFID.
International Journal of Eating Disorders
, 57
(11)
pp. 2167-2175.
10.1002/eat.24243.
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Abstract
Objective: Avoidant/restrictive food intake disorder (ARFID) is common among populations with nutrition-related medical conditions. Less is known about the medical comorbidity/complication frequencies in youth with ARFID. We evaluated the medical comorbidities and metabolic/nutritional markers among female and male youth with full/subthreshold ARFID across the weight spectrum compared with healthy controls (HC). Method: In youth with full/subthreshold ARFID (n = 100; 49% female) and HC (n = 58; 78% female), we assessed self-reported medical comorbidities via clinician interview and explored abnormalities in metabolic (lipid panel and high-sensitive C-reactive protein [hs-CRP]) and nutritional (25[OH] vitamin D, vitamin B12, and folate) markers. Results: Youth with ARFID, compared with HC, were over 10 times as likely to have self-reported gastrointestinal conditions (37% vs. 3%; OR = 21.2; 95% CI = 6.2–112.1) and over two times as likely to have self-reported immune-mediated conditions (42% vs. 24%; OR = 2.3; 95% CI = 1.1–4.9). ARFID, compared with HC, had a four to five times higher frequency of elevated triglycerides (28% vs. 12%; OR = 4.0; 95% CI = 1.7–10.5) and hs-CRP (17% vs. 4%; OR = 5.0; 95% CI = 1.4–27.0) levels. Discussion: Self-reported gastrointestinal and certain immune comorbidities were common in ARFID, suggestive of possible bidirectional risk/maintenance factors. Elevated cardiovascular risk markers in ARFID may be a consequence of limited dietary variety marked by high carbohydrate and sugar intake.
| Type: | Article |
|---|---|
| Title: | Medical Comorbidities, Nutritional Markers, and Cardiovascular Risk Markers in Youth With ARFID |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/eat.24243 |
| Publisher version: | https://doi.org/10.1002/eat.24243 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | allergy and immunology, avoidant/restrictive food intake disorder, DISEASE, feeding and eating disorders, food allergies, FOOD-INTAKE DISORDER, gastrointestinal disease, high-sensitive C-reactive protein, Life Sciences & Biomedicine, lipid panel, metabolic diseases, Nutrition & Dietetics, nutritional insufficiency, Psychiatry, Psychology, Psychology, Clinical, Science & Technology, Social Sciences, triglycerides |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10213412 |
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