Mahmoodi, Mahboobeh;
Darabi, Mohammad Ali;
Mohaghegh, Neda;
Erdem, Ahmet;
Ahari, Amir;
Abbasgholizadeh, Reza;
Tavafoghi, Maryam;
... Hassani Najafabadi, Alireza; + view all
(2024)
Egg White Photocrosslinkable Hydrogels as Versatile Bioinks for Advanced Tissue Engineering Applications.
Advanced Functional Materials
, 34
(32)
, Article 2315040. 10.1002/adfm.202315040.
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Abstract
Three dimensional (3D) bioprinting using photocrosslinkable hydrogels has gained considerable attention due to its versatility in various applications, including tissue engineering and drug delivery. Egg White (EW) is an organic biomaterial with excellent potential in tissue engineering. It provides abundant proteins, along with biocompatibility, bioactivity, adjustable mechanical properties, and intrinsic antiviral and antibacterial features. Here, a photocrosslinkable hydrogel derived from EW is developed through methacryloyl modification, resulting in Egg White methacryloyl (EWMA). Upon exposure to UV light, synthesized EWMA becomes crosslinked, creating hydrogels with remarkable bioactivity. These hydrogels offer adjustable mechanical and physical properties compatible with most current bioprinters. The EWMA hydrogels closely resemble the native extracellular matrix (ECM) due to cell-binding and matrix metalloproteinase-responsive motifs inherent in EW. In addition, EWMA promotes cell growth and proliferation in 3D cultures. It facilitates endothelialization when investigated with human umbilical vein endothelial cells (HUVECs), making it an attractive replacement for engineering hemocompatible vascular grafts and biomedical implants. In summary, the EWMA matrix enables the biofabrication of various living constructs. This breakthrough enhances the development of physiologically relevant 3D in vitro models and opens many opportunities in regenerative medicine.
| Type: | Article |
|---|---|
| Title: | Egg White Photocrosslinkable Hydrogels as Versatile Bioinks for Advanced Tissue Engineering Applications |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/adfm.202315040 |
| Publisher version: | https://doi.org/10.1002/adfm.202315040 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | 3D bioprinting, ADHESION, ANGIOGENESIS, BASEMENT-MEMBRANE, bioink, CADHERIN, Chemistry, Chemistry, Multidisciplinary, Chemistry, Physical, DIFFERENTIATION, egg white, endothelialization, GELATIN, hydrogels, Materials Science, Materials Science, Multidisciplinary, MATRIGEL, methacryloyl, Nanoscience & Nanotechnology, photocrosslinking, Physical Sciences, Physics, Physics, Applied, Physics, Condensed Matter, PROTEINS, SCAFFOLDS, Science & Technology, Science & Technology - Other Topics, STIFFNESS, Technology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office > Institute for Materials Discovery |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10213411 |
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