Alhammadi, Muna Abdalla;
Ilce, Burcu Yener;
Bhamidimarri, Poorna Manasa;
Bouzid, Amal;
Ali, Nival;
Alhamidi, Reem Sami;
Hamad, Alaa Mohamed;
... Hamoudi, Rifat; + view all
(2025)
Analysis of Genotype and Expression of FTO and ALKBH5 in a MENA-Region Renal Cell Carcinoma Cohort.
Cancers
, 17
(9)
, Article 1395. 10.3390/cancers17091395.
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Analysis of Genotype and Expression of FTO and ALKBH5 in a MENA-Region Renal Cell Carcinoma Cohort.pdf - Published Version Download (2MB) | Preview |
Abstract
RNA-modifying proteins play a key role in cancer progression. The fat mass and obesity-associated protein (FTO) and alkB homolog 5 (ALKBH5), two RNA demethylases, have opposing effects on renal cell carcinoma (RCC). This study investigates their genetic and expression profiles in RCC patients from the Middle East and Northern Africa (MENA) region. We found that the FTO rs11075995T variant is associated with an increased risk of clear-cell RCC (ccRCC). Both FTO and ALKBH5 levels were lower in ccRCC and chromophobe RCC (chRCC) patients compared to controls. We found a significant negative relationship in ccRCC between FTO levels and the frequency of the T allele in rs11075995. This suggests that the variant may affect FTO expression. This study is the first to show the dysregulated expression of FTO and ALKBH5 in ccRCC and chRCC patients from the MENA region.
| Type: | Article |
|---|---|
| Title: | Analysis of Genotype and Expression of FTO and ALKBH5 in a MENA-Region Renal Cell Carcinoma Cohort |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/cancers17091395 |
| Publisher version: | https://doi.org/10.3390/cancers17091395 |
| Language: | English |
| Additional information: | Copyright © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | renal cell carcinoma; FTO; ALKBH5; RNA-modifying proteins |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10213340 |
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