Abu Jayab, Nour;
Abed, Alaa;
Talaat, Iman M;
Hamoudi, Rifat;
(2025)
The molecular mechanism of NF-KB dysregulation across different subtypes of renal cell carcinoma.
Journal of Advanced Research
, 72
pp. 501-514.
10.1016/j.jare.2024.07.030.
Preview |
Text
Hamoudi_1-s2.0-S209012322400314X-main.pdf Download (1MB) | Preview |
Abstract
BACKGROUND: The nuclear factor kappa B (NF-κB) is a critical pathway that regulates various cellular functions, including immune response, proliferation, growth, and apoptosis. Furthermore, this pathway is tightly regulated to ensure stability in the presence of immunogenic triggers or genotoxic stimuli. The lack of control of the NF-κB pathway can lead to the initiation of different diseases, mainly autoimmune diseases and cancer, including Renal cell carcinoma (RCC). RCC is the most common type of kidney cancer and is characterized by complex genetic composition and elusive molecular mechanisms. AIM OF REVIEW: The current review summarizes the mechanism of NF-κB dysregulation in different subtypes of RCC and its impact on pathogenesis. KEY SCIENTIFIC CONCEPT OF REVIEW: This review highlights the prominent role of NF-κB in RCC development and progression by driving the expression of multiple genes and interplaying with different pathways, including the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway. In silico analysis of RCC cohorts and molecular studies have revealed that multiple NF-κB members and target genes are dysregulated. The dysregulation includes receptors such as TLR2, signal-transmitting members including RelA, and target genes, for instance, HIF-1α. The lack of effective regulatory mechanisms results in a constitutively active NF-κB pathway, which promotes cancer growth, migration, and survival. In this review, we comprehensively summarize the role of dysregulated NF-κB-related genes in the most common subtypes of RCC, including clear cell RCC (ccRCC), chromophobe RCC (chRCC), and papillary RCC (PRCC).
| Type: | Article |
|---|---|
| Title: | The molecular mechanism of NF-KB dysregulation across different subtypes of renal cell carcinoma |
| Location: | Egypt |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jare.2024.07.030 |
| Publisher version: | https://doi.org/10.1016/j.jare.2024.07.030 |
| Language: | English |
| Additional information: | © 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Renal cell carcinoma, Genetic modification, NF-jB dysregulation, Molecular mechanism |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10213335 |
Archive Staff Only
 |
View Item |
