Villalobos, Elisa;
Mehra, Priyanka;
Diaz-Manera, Jordi;
(2025)
From fibro/adipogenic progenitors to adipocytes: Understanding adipogenesis in muscle degeneration for disease modulation.
The Journal of Physiology
, Article JP288924. 10.1113/JP288924.
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Abstract
Fibro/adipogenic progenitors (FAPs) are muscle-resident stem cells essential for muscle regeneration because of their ability to differentiate into adipocytes and fibroblasts. This differentiation contributes to tissue remodelling and is implicated in the accumulation of fat and fibrotic tissue seen in neuromuscular, cardiovascular and degenerative diseases. FAPs also interact with other muscle cells and modulate inflammation, playing a central role in muscle degeneration across various disease contexts. This review summarises current knowledge on FAP adipogenic differentiation in muscle degeneration and regeneration, with a focus on cardiovascular and neuromuscular diseases, which share common features of impaired muscle remodelling. We discuss established methods for culturing, maintaining, and differentiating FAPs in vitro to support future research. Additionally, we examine FAP subpopulations, key signalling pathways and pharmacological agents influencing FAP differentiation into adipocytes. Understanding these mechanisms offers promising avenues for developing therapeutic strategies to restore muscle homeostasis and slow down pathological muscle remodelling. (Figure presented.).
| Type: | Article |
|---|---|
| Title: | From fibro/adipogenic progenitors to adipocytes: Understanding adipogenesis in muscle degeneration for disease modulation |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1113/JP288924 |
| Publisher version: | https://doi.org/10.1113/jp288924 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Physiology, Neurosciences & Neurology, adipogenesis, fibrosis, FAPs, fibro/adipogenic progenitors, muscle, remodelling, DUCHENNE MUSCULAR-DYSTROPHY, SKELETAL-MUSCLE, NITRIC-OXIDE, STEM-CELLS, INHIBITS ADIPOGENESIS, SIGNALING PATHWAYS, FATTY INFILTRATION, REGENERATION, ACTIVATION, RECEPTOR |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10213191 |
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