Murphy, Ethan;
Dakhili, Amir Hossein;
Ganesan, Saampras;
Zalesky, Andrew;
Glarin, Rebecca;
Thomson, Hannah;
Paloubis, Anastasia;
... Lorenzetti, Valentina; + view all
(2025)
CannChange: a protocol for a feasibility study using fMRI-based neurofeedback to change the neurobiology of craving in cannabis use disorder.
BMJ Open
, 15
(8)
, Article e105854. 10.1136/bmjopen-2025-105854.
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Murphy....Lorenzetti 2025 CannChange_a protocol for a feasibility study using fMRI-based neurofeedback to change the neurobiology of craving in cannabis use disorder.pdf - Published Version Download (1MB) | Preview |
Abstract
Introduction Cannabis use disorder (CUD) affects ∼33 million people globally and can be underscored by intense cravings to use cannabis, which can trigger compulsive use and relapse. Functional MRI (fMRI) evidence demonstrates hyperactivity of addiction brain pathways during cannabis cue-reactivity, consistent with prominent neuroscientific theories of addiction, particularly within the anterior cingulate cortex (ACC). The ACC also emerges as a key region of real-time fMRI-based neurofeedback (fMRI-neurofeedback) studies demonstrating voluntary changes during cravings in persons who use substances. However, this notion is untested in CUD. Methods and analysis We aim to develop a protocol that tests the feasibility of fMRI-neurofeedback to enable persons with a moderate-to-severe CUD to increase the activity of the ACC during cannabis-induced craving to provide mechanistic insights on treatment targets; and decrease ACC activity during cue-induced craving to pave the way for reducing brain reactivity. The primary outcome measure is the change in ACC activity during fMRI-neurofeedback compared with a non-regulation condition. Ethics and dissemination This feasibility study has been approved by the Human Research Ethics Committee of Australian Catholic University. On completion, the findings from this study will be published in academic journals, presented at conferences and disseminated to clinicians and to individuals who use cannabis. The results from this feasibility study have the potential to inform the conduct of powered trials to examine how fMRI-neurofeedback can identify and reduce craving-related brain dysfunction in CUD.
| Type: | Article |
|---|---|
| Title: | CannChange: a protocol for a feasibility study using fMRI-based neurofeedback to change the neurobiology of craving in cannabis use disorder |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/bmjopen-2025-105854 |
| Publisher version: | https://doi.org/10.1136/bmjopen-2025-105854 |
| Language: | English |
| Additional information: | https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10213137 |
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