Janbek, Janet;
Laursen, Thomas Munk;
Jørgensen, Kasper;
Jensen, Martin Mejlby;
Eliasen, Marie Holm;
Christensen, Anne Illemann;
Walsh, Sebastian;
... Waldemar, Gunhild; + view all
(2025)
Prevalence and co-occurrence of dementia risk factors in Denmark: A nationwide study.
The Journal of Prevention of Alzheimer's Disease
, Article 100365. 10.1016/j.tjpad.2025.100365.
(In press).
Preview |
Text
Janbek - Co-occurrence of dementia risk factors.pdf - Published Version Download (2MB) | Preview |
Abstract
Background: The clustering of dementia risk factors is common and has implications for policies targeting risk reduction. Objectives: To estimate the prevalence of 16 dementia risk factors and their co-occurrence. Design: Cross-sectional based on a closed cohort on 1 January 2022 with nationwide data on risk factors from 1969/1977. Setting: Denmark Participants: Whole population; closed cohort of individuals ≥65 years on 1 January 2022, and a subpopulation of responders in the 2010/2013 Danish National Health Survey. Intervention (exposures): Sixteen dementia risk factors: hypertension, cardiovascular disease, diabetes, hypercholesterolemia, obesity, smoking, alcohol, physical inactivity, depression, hearing loss, vision impairment, traumatic brain injury, sleep disorders, hospital-diagnosed infections, social isolation, and low education. Measurements: Period and point prevalence proportions of the dementia risk factors and of all possible combinations of factors (those occurring in ≥10 % of individuals). The prevalence estimates reflect a population-level view of persons who have experienced, were diagnosed, or were treated for the risk factors assessed. Results: In the whole population (N = 1,214,286) and the subpopulation (N = 88,565), 5 % had no risk factors, 12 % had only one, and 82 % had multiple. Hypertension was the most prevalent (57 %), and vision impairment the least (2 %). Men, individuals ≥85 years, and those with low education had the highest prevalence of risk factors (with exceptions). Conclusions: Clustering of risk factors is very common, and findings emphasize the need to focus on multidomain interventions for dementia risk reduction that account for the clustering of risk.
| Type: | Article |
|---|---|
| Title: | Prevalence and co-occurrence of dementia risk factors in Denmark: A nationwide study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tjpad.2025.100365 |
| Publisher version: | https://doi.org/10.1016/j.tjpad.2025.100365 |
| Language: | English |
| Additional information: | © 2025 The Author(s). Published by Elsevier Masson SAS on behalf of SERDI Publisher. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| Keywords: | Dementia, Risk factors, Co-occurrence, Nationwide, Population-based |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry > Mental Health of Older People |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10212993 |
Archive Staff Only
 |
View Item |
