Williams, Chloe EC;
Marro, Julien;
Chetwynd, Andrew J;
Brown, Joseph;
Skoutelis, Nikolaos;
Dliso, Silothabo;
McBurney, Catherine;
(2025)
The IgA Vasculitis Study: the evolution of a cross-sectional cohort into a trial-ready cohort.
Rheumatology Advances in Practice
, Article rkaf099. 10.1093/rap/rkaf099.
(In press).
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Abstract
OBJECTIVES: The aim of this report is to describe a single centre cohort study and its evolutionary stages into a trial-ready cohort with the vision of stopping kidney failure secondary to IgAV. METHODS: The IgA Vasculitis Study was established as a single-centre, cross-sectional cohort study recruiting children with a clinical diagnosis of IgAV and has evolved into a trial-ready framework. Sociodemographic and clinical data, as well as corresponding biosamples, were collected longitudinally and the natural history of the first 100 recruits is provided. RESULTS: The IgA Vasculitis Study commenced in June 2019. The first 100 children recruited to the study had a mean age of 7.3 ± 3.7 years, male: female ratio 1.5:1. At presentation, all children had a lower limb-predominant rash, 76% had musculoskeletal involvement, 43% gastrointestinal involvement, and 23% met the definition of nephritis. Most children (54%) were discharged after six months, however 17% required paediatric nephrology input. The mean timing of onset for nephritis was 25.5 ± 22.9 days following disease presentation (range 0.0–101 days). Fourteen children with IgAV-N received immunosuppression. Children with an older age, residing in more affluent areas, had GI involvement, or had a positive urine dipstick (for proteinuria and/or haematuria) at presentation had a greater odds ratio for developing nephritis. Children with IgAV-N had statistically significantly more hospital visits and unplanned hospital admissions (p < 0.001). CONCLUSION: Nephritis remains a serious consequence of IgAV with little evidence to guide management, and this report outlines an exemplar study to advance the field towards better interventions.
| Type: | Article |
|---|---|
| Title: | The IgA Vasculitis Study: the evolution of a cross-sectional cohort into a trial-ready cohort |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/rap/rkaf099 |
| Publisher version: | https://doi.org/10.1093/rap/rkaf099 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2025. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Henoch-Schoenlein purpura, paediatric, children, kidney, nephritis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10212904 |
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