Chen, Xiaojuan;
Liu, Xiaoning;
Li, Fengjuan;
He, Haitian;
Li, Xinying;
Qin, Tianhang;
Jiang, Bin;
... Qin, Pei; + view all
(2025)
Depression and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.
Transl Psychiatry
, 15
, Article 298. 10.1038/s41398-025-03463-8.
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Abstract
BACKGROUND: Currently, most studies of depression are limited to a single disease endpoint. AIMS: This study aimed to conduct an umbrella review to comprehensively assess the association between depression and health outcomes. METHOD: Until December 17, 2024, we conducted a systematic search of systematic reviews and meta-analyses in PubMed, Embase, and Web of Science. We reanalyzed the summary effects and 95% confidence intervals for each study using random models. We assessed the methodological quality and evidence quality of the research with A Measurement Tool to Assess Systematic Reviews 2 and Grade of Recommendations, Assessment, Development and Evaluation, classifying studies into four categories based on evidence classification criteria. RESULTS: We selected a total of 72 articles from 27,150 resulting in 114 meta-analyses and 109 health outcomes. Depression exposure was associated with 23 mortality, 21 cardiovascular outcomes, 15 offspring outcomes, 9cancer outcomes, 9 neurological outcomes, 5 endocrine outcomes, 5 dental outcomes, 3 digestive outcomes, and 19 other health outcomes. Moderate-quality evidence linked depression to specific mortality in bladder cancer (Class IV), all-cause mortality in myocardial infarction (Class III), mortality within 2 years of initial assessment in coronary artery disease (Class IV), major adverse cardiovascular events after percutaneous coronary intervention (Class III), irritable bowel syndrome (insignificant), fear of falling (Class III), and frailty (Class III). CONCLUSIONS: Depression has a significant impact on health outcomes, primarily mortality and cardiovascular outcomes. However, more definitive conclusions still require randomized controlled trials or prospective studies for validation.
| Type: | Article |
|---|---|
| Title: | Depression and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41398-025-03463-8 |
| Publisher version: | https://doi.org/10.1038/s41398-025-03463-8 |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Depression, Diseases |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10212835 |
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