UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Anti–Glomerular Basement Membrane Disease: Recent Updates

Bharati, Joyita; Jhaveri, Kenar D; Salama, Alan D; Oni, Louise; (2024) Anti–Glomerular Basement Membrane Disease: Recent Updates. Advances in Kidney Disease and Health , 31 (3) pp. 206-215. 10.1053/j.akdh.2024.04.007. Green open access

[thumbnail of Salama_Anti-glomerular basement membrane disease_ recent updates_VoR.pdf]
Preview
Text
Salama_Anti-glomerular basement membrane disease_ recent updates_VoR.pdf

Download (1MB) | Preview

Abstract

Anti–glomerular basement membrane disease is a small-vessel vasculitis involving the kidneys (∼90%) and the lungs (∼60%). Antibodies against the glomerular basement membrane are directly pathogenic in anti–glomerular basement membrane disease; however, recent research has highlighted the critical role of T cells. Novel autoantigens within the glomerular basement membrane are also now recognized. Atypical forms of the disease are reported along with preceding triggers, such as immune checkpoint inhibitors, immunomodulatory drugs, and vaccines. Kidney outcomes in anti–glomerular basement membrane disease remain poor despite significant improvement in patient survival in the last 2 to 3 decades. Treatment typically relies on combined plasmapheresis with intensive immunosuppression. Dialysis dependency at presentation is a dominant predictor of kidney outcome. Histologically, a low (<10%) percentage of normal glomeruli, 100% crescents, together with dialysis dependency at presentation, is associated with poor kidney outcomes. In such cases, an individualized approach weighing the risks and benefits of treatment is recommended. There is a need for better ways to stop the toxic inflammatory activity associated with this disease. In this narrative review, we discuss recent updates on the pathogenesis and management of anti–glomerular basement membrane disease relevant to patients of all ages.

Type: Article
Title: Anti–Glomerular Basement Membrane Disease: Recent Updates
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1053/j.akdh.2024.04.007
Publisher version: https://doi.org/10.1053/j.akdh.2024.04.007
Language: English
Additional information: © 2024 Published by Elsevier Inc. on behalf of the National Kidney Foundation, Inc. under a Creative Commons license (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10212640
Downloads since deposit
8Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item