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Personalized uncertainty quantification in artificial intelligence

Chakraborti, Tapabrata; Banerji, Christopher RS; Marandon, Ariane; Hellon, Vicky; Mitra, Robin; Lehmann, Brieuc; Bräuninger, Leandra; ... MacArthur, Ben; + view all (2025) Personalized uncertainty quantification in artificial intelligence. Nature Machine Intelligence , 7 pp. 522-530. 10.1038/s42256-025-01024-8.

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Abstract

Artificial intelligence (AI) tools are increasingly being used to help make consequential decisions about individuals. While AI models may be accurate on average, they can simultaneously be highly uncertain about outcomes associated with specific individuals or groups of individuals. For high-stakes applications (such as healthcare and medicine, defence and security, banking and finance), AI decision-support systems must be able to make personalized assessments of uncertainty in a rigorous manner. However, the statistical frameworks needed to do so are currently incomplete. Here, we outline current approaches to personalized uncertainty quantification (PUQ) and define a set of grand challenges associated with the development and use of PUQ in a range of areas, including multimodal AI, explainable AI, generative AI and AI fairness.

Type: Article
Title: Personalized uncertainty quantification in artificial intelligence
DOI: 10.1038/s42256-025-01024-8
Publisher version: https://doi.org/10.1038/s42256-025-01024-8
Language: English
Additional information: This version is the author-accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions
Keywords: Mathematics and computing, Scientific community, Statistics.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Statistical Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
URI: https://discovery.ucl.ac.uk/id/eprint/10212111
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