Sing, Chor-Wing;
Chan, Koon-Ho;
Chiu, Patrick KC;
Lau, Wallis CY;
Zhang, Xiaowen;
Tan, Kathryn CB;
Cheung, Ching-Lung;
(2025)
Bisphosphonates and the risk of dementia in patients with osteoporosis or fragility fracture: A population-based study in Hong Kong.
Alzheimer's & Dementia
, 21
(7)
, Article e70503. 10.1002/alz.70503.
Preview |
Text
Bisphosphonates and the risk of dementia in patients with osteoporosis or fragility fracture A population-based study in Hon.pdf - Published Version Download (900kB) | Preview |
Abstract
INTRODUCTION: Emerging evidence suggests neuroprotective effects of bisphosphonates. We aim to investigate whether nitrogen-containing bisphosphonates (NBPs) could reduce the risk of Alzheimer's disease and related dementia (ADRD). // METHODS: We identified patients aged 60+ with osteoporosis or fragility fracture in 2005–2020 from a healthcare database in Hong Kong. Patients receiving NBPs were 1:1 matched with untreated patients and those receiving other anti-osteoporosis medications (“non-NBPs”) by time-dependent propensity score. Follow-up was conducted until December 31, 2021. Cause-specific hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using the Cox proportional hazard model. // RESULTS: Among 121,492 patients (NBP = 15,654, non-NBP = 6331), we matched 10,833 pairs for NBPs-vs-untreated and 3080 pairs for NBPs-vs-non-NBPs. NBP use was associated with a lower risk of ADRD compared to untreated (HR = 0.84, 95% CI = 0.78–0.90) and non-NBP (HR = 0.76, 95% CI = 0.66–0.89). // DISCUSSION: NBP use was associated with a lower risk of dementia, suggesting further studies are warranted on its potential to improve cognitive function.
| Type: | Article |
|---|---|
| Title: | Bisphosphonates and the risk of dementia in patients with osteoporosis or fragility fracture: A population-based study in Hong Kong |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/alz.70503 |
| Publisher version: | https://doi.org/10.1002/alz.70503 |
| Language: | English |
| Additional information: | Copyright © 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Alzheimer’s disease, antiresorptives, bisphosphonates, dementia, osteoporosis, pharmacoepidemiology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10212034 |
Archive Staff Only
 |
View Item |
