Lee, Irene O;
Fritsch, Dennis M;
Kerz, Maximilian;
Sowden, Jane C;
Constable, Paul A;
Skuse, David H;
Thompson, Dorothy A;
(2025)
Global motion coherent deficits in individuals with autism spectrum disorder and their family members are associated with retinal function.
Scientific Reports
, 15
, Article 28249. 10.1038/s41598-025-11789-y.
Preview |
Text
Lee_et_al-2025_Motion coherence_Scientific_Reports.pdf - Published Version Download (3MB) | Preview |
Abstract
This study aims to evaluate if the reduced sensitivity to global motion observed in some individuals with autism spectrum disorder (ASD) is associated with altered retinal processing. Motion coherence thresholds were measured from individuals with ASD and their family members and compared to the test reference limits derived from control participants. The light adapted electroretinogram (ERG) a- and b-wave amplitudes and peak-times, and photopic negative response (PhNR) parameters were measured from the ASD individuals and their families and compared to those of controls. Abnormally high motion coherence thresholds were found in ASD probands and their family members compared to that in controls, particularly mothers. Altered retinal functions were found in ASD probands and their parents. The PhNR, a- and b-wave time-to-peak were significantly correlated with motion coherence thresholds. The altered retinal function was associated with the age, intelligence and autism severity of the ASD family members. There were associations between the motion coherence and ERG parameters, including smaller amplitudes of the PhNR, and longer time-to-peak of the a- and b-waves and time to the PhNR, compared to those with abnormal motion coherence thresholds. The results showed that global motion coherence deficits were associated with altered retinal function in ASD and their family members. The findings suggest that motion perception deficits follow a familial pattern and that affected mothers may have an increased risk of a child with ASD.
| Type: | Article |
|---|---|
| Title: | Global motion coherent deficits in individuals with autism spectrum disorder and their family members are associated with retinal function |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41598-025-11789-y |
| Publisher version: | https://doi.org/10.1038/s41598-025-11789-y |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Global motion perception; Electroretinogram; Coherent motion; Retinal function; Magnocellular pathway; Autism family |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10211893 |
Archive Staff Only
 |
View Item |
