Forbes, Miriam K;
Baillie, Andrew;
Batterham, Philip J;
Calear, Alison;
Kotov, Roman;
Krueger, Robert F;
Markon, Kristian E;
... Anna Clark, Lee; + view all
(2025)
Reconstructing Psychopathology: A Data-Driven Reorganization of the Symptoms in the Diagnostic and Statistical Manual of Mental Disorders.
Clinical Psychological Science
, 13
(3)
pp. 462-488.
10.1177/21677026241268345.
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Abstract
In this study, we reduced the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) to its constituent symptoms and reorganized them based on patterns of covariation in individuals’ (N = 14,762) self-reported experiences of the symptoms to form an empirically derived hierarchical framework of clinical phenomena. Specifically, we used the points of agreement among hierarchical principal components analyses and hierarchical clustering as well as between the randomly split primary (n = 11,762) and hold-out (n = 3,000) samples to identify the robust constructs that emerged to form a hierarchy ranging from symptoms and syndromes up to very broad superspectra of psychopathology. The resulting model had noteworthy convergence with the upper levels of the Hierarchical Taxonomy of Psychopathology (HiTOP) framework and substantially expands on HiTOP’s current coverage of dissociative, elimination, sleep–wake, trauma-related, neurodevelopmental, and neurocognitive disorder symptoms. We also mapped some exemplar DSM-5 disorders onto our hierarchy; some formed coherent syndromes, whereas others were notably heterogeneous.
| Type: | Article |
|---|---|
| Title: | Reconstructing Psychopathology: A Data-Driven Reorganization of the Symptoms in the Diagnostic and Statistical Manual of Mental Disorders |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/21677026241268345 |
| Publisher version: | https://doi.org/10.1177/21677026241268345 |
| Language: | English |
| Additional information: | © The Author(s) 2024. Creative Commons License (CC BY-NC 4.0) This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| Keywords: | Social Sciences, Science & Technology, Life Sciences & Biomedicine, Psychology, Clinical, Psychiatry, Psychology, classification, diagnosis, psychopathology, DSM, HiTOP, PERSONALITY-TRAIT MODEL, HIERARCHICAL TAXONOMY, VALIDITY, HITOP, UTILITY, DYSFUNCTION, VALIDATION, DIMENSIONS, INVENTORY, CONSENSUS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10211601 |
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