Rosbergen, Mathijs T;
Van der Veere, Pieter;
Claus, Jacqueline J;
Evans, Tavia E;
Venkatraghavan, Vikram;
Barkhof, Frederik;
Van Harten, Argonde C;
... Wolters, Frank J; + view all
(2025)
Subcortical gray matter volumes and 5-year dementia risk in individuals with subjective cognitive decline or mild cognitive impairment: A multi-cohort analysis.
Alzheimer's & Dementia
, 21
(7)
, Article e70413. 10.1002/alz.70413.
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Abstract
INTRODUCTION: The prognostic value of subcortical gray matter structures for dementia beyond the hippocampus remains unclear. // METHODS: We included participants with subjective cognitive decline or mild cognitive impairment from two memory clinic-based cohorts (Amsterdam Dementia Cohort and National Alzheimer's Coordinating Center) and one population-based cohort (Rotterdam Study). We assessed volumes of subcortical structures on magnetic resonance imaging and determined 5-year dementia risk using Cox models. // RESULTS: Of 7076 participants (mean age: 66–69 years, 58.8%–61.0% women; NSCC = 5425, NMCI = 1661), 622 developed dementia within 5 years. Smaller volumes of the hippocampus and amygdala were consistently associated with increased dementia risk, independent of other subcortical structures. Smaller hippocampal volume was predominantly associated with the clinical diagnosis of Alzheimer's disease, but the prognostic value did not differ by amyloid status. // DISCUSSION: Hippocampal and amygdalar volume are consistently associated with dementia risk in individuals with subjective cognitive decline or mild cognitive impairment, which may hold potential for personalized prognosis.
| Type: | Article |
|---|---|
| Title: | Subcortical gray matter volumes and 5-year dementia risk in individuals with subjective cognitive decline or mild cognitive impairment: A multi-cohort analysis |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/alz.70413 |
| Publisher version: | https://doi.org/10.1002/alz.70413 |
| Language: | English |
| Additional information: | Copyright © 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Alzheimer’s disease, dementia, magnetic resonance imaging, neuroimaging, subcortical structures |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10211536 |
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