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Mechanisms of Protein Seeding in Neurodegenerative Diseases

Walker, Lary C; Diamond, Marc I; Duff, Karen E; Hyman, Bradley T; (2013) Mechanisms of Protein Seeding in Neurodegenerative Diseases. JAMA Neurology , 70 (3) pp. 304-310. 10.1001/jamaneurol.2013.1453. Green open access

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Abstract

A growing body of data indicates that the propagation of pathogenic protein aggregates across neural systems, and hence the disruption of function of those neural systems, might be mediated by misfolded protein seeds that are released and taken up by anatomically connected neurons. If so, blocking this process may help arrest the progression of disease. In light of the growing spectrum of disorders involving the accumulation and spread of misfolded proteins, efforts to detect pathogenic protein aggregates and impede their movement between cells could change how we diagnose and treat neurodegenerative diseases. © 2013 American Medical Association. All rights reserved.

Type: Article
Title: Mechanisms of Protein Seeding in Neurodegenerative Diseases
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1001/jamaneurol.2013.1453
Publisher version: https://doi.org/doi:10.1001/jamaneurol.2013.1453
Language: English
Additional information: This version is the author-accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10211409
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