Stelmashchuk, Olga A;
Dremin, Victor V;
Abramov, Andrey Y;
(2025)
Laser-generated singlet oxygen is protective against beta-amyloid neurotoxicity.
Life Sciences
, 378
, Article 123823. 10.1016/j.lfs.2025.123823.
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Abstract
β-Amyloid is the peptide which forms extracellular senile plaques in Alzheimer’s disease. Link of the β-amyloid to inherited form of Alzheimer’s disease and neurotoxicity of aggregated peptide has been suggested to the involvement of β-amyloid in the mechanism of pathology of this devastating disease. The toxicity of aggregated βamyloid is triggered by changes in calcium signal, mitochondrial energy metabolism and oxidative stress. Laser (1267nm)-induced singlet oxygen is shown to be able to modify proteins and accelerate energy metabolism that potentially may modify the effects of βamyloid. Using primary co-culture of neurons and astrocytes we studied the effect of laser-generated singlet oxygen on β-amyloid-induced calcium signal, mitochondrial energy metabolism and oxidative stress. We have found that singlet oxygen prevents aggregation of the full peptide βA 1-42, reduces the effect of β-amyloid on cytosolic and mitochondrial calcium elevation, reduces mitochondrial depolarization and depletion of NADH in mitochondria. As result it protected neurons and astrocytes against β-amyloidinduced cell death. Thus, singlet oxygen could play neuroprotective role.
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