Campanilho-Marques, Raquel;
Fonseca, João Eurico;
Machado, Pedro M;
(2025)
Treatment of idiopathic inflammatory myopathies.
Joint Bone Spine
, 92
(6)
, Article 105932. 10.1016/j.jbspin.2025.105932.
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Abstract
Adult idiopathic inflammatory myopathies (IIMs) are rare autoimmune disorders affecting multiple organs, making diagnosis and treatment challenging. Current management relies on immunosuppressants like corticosteroids, methotrexate, azathioprine, mycophenolate mofetil, rituximab, and intravenous immunoglobulin, though treatment responses vary across patients and subtypes. Despite substantial challenges in clinical research, such as patient recruitment, misdiagnoses from overlapping symptoms with other conditions, and inconsistencies in disease classification, the growing number of myositis-specific clinical trials provides optimism. Progress in targeted therapies has the potential to refine treatment approaches, support the development of more standardized, evidence-based guidelines, and ultimately enhance patient outcomes. In this paper, we aim to provide a review of the current therapeutic options based on IIM subtypes.
| Type: | Article |
|---|---|
| Title: | Treatment of idiopathic inflammatory myopathies |
| Location: | France |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jbspin.2025.105932 |
| Publisher version: | https://doi.org/10.1016/j.jbspin.2025.105932 |
| Language: | English |
| Additional information: | Copyright © 2025 The Author(s). Published by Elsevier Masson SAS on behalf of Societe´ Francaise de Rhumatologie. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Dermatomyositis; Immune-mediated necrotizing myopathy; Anti-synthetase syndrome; Inclusion body myositis; Immunosuppressive therapy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10211221 |
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