Pathak, Sanmoy;
Hogan, Thea;
Rane, Sanket;
Huang, Yundi;
Pearson, Claire;
Sinclair, Charles;
Barry, Simon;
... Seddon, Benedict; + view all
(2025)
A linear ontogeny accounts for the development of naive, memory, and tumor-infiltrating regulatory T cells in mice.
Science Immunology
, 10
(108)
, Article eadu7341. 10.1126/sciimmunol.adu7341.
Preview |
Text
Pathak et al 2025.pdf - Accepted Version Download (4MB) | Preview |
Abstract
Regulatory T cells (Treg cells) are critical regulators of adaptive immunity and the pathophysiology of antitumoral immunity. Treg cells are both generated during thymic development and induced from peripheral conventional T cells. How these distinct pathways contribute to the homeostasis of circulating Treg cells in health and disease remains unclear. We addressed this question using multiple fate-mapping mouse systems and modeling. Naive and effector/memory (EM) Treg cells exhibit distinct dynamics but are both continuously replenished by de novo generation throughout life. The predominant precursors of circulating EM Treg cells are naive thymic Treg cells and not conventional T cells, a process driven by self rather than foreign antigen recognition. Using the same fate reporters and three tumor models, we demonstrate that infiltrating Treg cells specifically derive from preexisting EM Treg cells. In summary, we define a linear ontogeny of Treg cells from the thymus to EM, driven by self-antigen recognition, that then gives rise to tumor-infiltrating Treg cells.
| Type: | Article |
|---|---|
| Title: | A linear ontogeny accounts for the development of naive, memory, and tumor-infiltrating regulatory T cells in mice |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1126/sciimmunol.adu7341 |
| Publisher version: | https://doi.org/10.1126/sciimmunol.adu7341 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10211195 |
Archive Staff Only
 |
View Item |
