Panteleienko, L;
Mallon, D;
Htet, CMM;
Lizak, N;
Zandi, M;
Banerjee, G;
Werring, DJ;
(2025)
Cerebral Amyloid Angiopathy-Related Inflammation in Iatrogenic Cerebral Amyloid Angiopathy.
European Journal of Neurology
, 32
(5)
, Article e70198. 10.1111/ene.70198.
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Abstract
INTRODUCTION: Cerebral amyloid angiopathy (CAA) related inflammation (CAA-ri) is considered to be a distinct syndrome caused by an inflammatory response to amyloid-β deposition in the walls of small leptomeningeal and cortical vessels in patients with sporadic CAA. However, recent data suggest that inflammation might contribute to a broader range of CAA subtypes. RESULTS: We describe a case of probable iatrogenic CAA (iCAA), which manifested with multiple intracerebral haemorrhages complicated by the development of clinical and radiological features of CAA-ri, which responded to steroids. Clinical, neuroimaging and CSF data suggested possible co-existing Alzheimer's pathology. DISCUSSION: CAA-ri may occur in association with iCAA, suggesting that a broader spectrum of patients might benefit from steroid treatment than previously assumed.
| Type: | Article |
|---|---|
| Title: | Cerebral Amyloid Angiopathy-Related Inflammation in Iatrogenic Cerebral Amyloid Angiopathy |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/ene.70198 |
| Publisher version: | https://doi.org/10.1111/ene.70198 |
| Language: | English |
| Additional information: | © 2025 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | amyloid‐beta, cadaveric dura mater, cerebral amyloid angiopathy‐related inflammation, iatrogenic cerebral amyloid angiopathy, prion, Humans, Cerebral Amyloid Angiopathy, Cerebral Hemorrhage, Iatrogenic Disease, Inflammation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10211133 |
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